منابع مشابه
Cardiovascular, Pulmonary and Renal Pathology Experimental Autoimmune Vasculitis An Animal Model of Antineutrophil Cytoplasmic Autoantibody-Associated Systemic Vasculitis
The morbidity burden associated with anti-neutrophil cytoplasmic autoantibody-associated vasculitis is increasing, and many novel biological therapies are now entering the drug development pipeline. There is thus an urgent need to develop a representative animal model to facilitate testing of these agents. We previously examined the effect of antineutrophil cytoplasmic autoantibody on leukocyte...
متن کاملExercise-induced vasculitis associated with autoimmune disease.
Exercised-induced vasculitis (EIV) is an underreported and frequently misdiagnosed condition that occurs on the lower extremities shortly after exercise. Most reported cases have presented in healthy-appearing individuals, but some cases have been linked to other disease processes. A case report is presented of recurring EIV in a 65-year-old woman with a history of dermatitis herpetiformis; chr...
متن کاملChecks and Balances in Autoimmune Vasculitis
Age-associated changes in the immune system including alterations in surface protein expression are thought to contribute to an increased susceptibility for autoimmune diseases. The balance between the expression of coinhibitory and costimulatory surface protein molecules, also known as immune checkpoint molecules, is crucial in fine-tuning the immune response and preventing autoimmunity. The a...
متن کاملSystemic vasculitis complicating infantile autoimmune enteropathy.
An infant with unexplained sideroblastic anaemia and severe protracted diarrhoea due to autoimmune gut disease is reported. Despite treatment with an exclusion diet and immunosuppressive agents she developed a severe systemic vasculitic illness. Intensive treatment with plasmapheresis resulted in resolution of the vasculitic process but the child subsequently died after overwhelming septicaemia.
متن کاملAntibody Glycosylation Predicts Relapse in Autoimmune Vasculitis
Article history: Received 9 February 2017 Accepted 9 February 2017 Available online 10 February 2017 non-relapsing patients the glycosylation profiles did not change. Somewhat surprising, PR3-ANCA galactosylation, sialylation, and fucosylation decreased in both relapsing and non-relapsing patients. It has been known for some30years now thatmanifest autoimmune disease is correlated with changes ...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2009
ISSN: 0002-9440
DOI: 10.2353/ajpath.2009.080458